(S)-(+)-6-甲基-1-辛醇合成路线 （共 15 条）
反应条件
hydrogen; palladium on activated charcoal in methanol P=760.051 Torr; 6 h;
参考文献
Tetrahedron, , vol. 60, # 43 SPEC. ISS. p. 9543 - 9558
反应条件
water; toluene-4-sulfonic acid in methanol
参考文献
Bestmann, Hans Juergen; Frighetto, Rosa T. S.; Frighetto, Nelson; Vostrowsky, Otto
Liebigs Annalen der Chemie, 1988 , p. 877 - 880
反应条件
lithium aluminium tetrahydride in diethyl ether 2 h; Ambient temperature;
参考文献
Tolstikov, A. G.; Khakhalina, N. V.; Savateeva, E. E.; Spirikhin, L. V.; Odinokov, V. N.; Tolstikov, G. A.
Chemistry of Natural Compounds, 1991 , vol. 27, # 5 p. 624 - 628
Khimiya Prirodnykh Soedinenii, 1991 , # 5 p. 707 - 712
反应条件
1: Dibal-H / diethyl ether; hexane / 2 h / 0 °C 2: H2 / Pd/C / methanol / 6 h / 760.05 Torr View Scheme
参考文献
Tetrahedron, , vol. 60, # 43 SPEC. ISS. p. 9543 - 9558
反应条件
1: 1.) n-C4H9Li, 2.) BF3*(C2H5)2O 2: 93 percent / H2 / 10percent Pd/C / methanol / 12 h / 25 °C 3: 72 percent / pyridine / 24 h / Ambient temperature 4: 70 percent / LiAlH4 / diethyl ether / 2 h / Ambient temperature View Scheme
参考文献
Chemistry of Natural Compounds, , vol. 27, # 5 p. 624 - 628
Khimiya Prirodnykh Soedinenii, , # 5 p. 707 - 712
反应条件
1: 93 percent / H2 / 10percent Pd/C / methanol / 12 h / 25 °C 2: 72 percent / pyridine / 24 h / Ambient temperature 3: 70 percent / LiAlH4 / diethyl ether / 2 h / Ambient temperature View Scheme
参考文献
Chemistry of Natural Compounds, , vol. 27, # 5 p. 624 - 628
Khimiya Prirodnykh Soedinenii, , # 5 p. 707 - 712
反应条件
1: 78 percent / POCl3 2: (C2H5)3N / tetrahydrofuran / 2 h / Ambient temperature 3: 90 percent / 3N H2SO4 / dioxane / 4 h / Heating 4: 87 percent / LiAlH4, MeOH / tetrahydrofuran / 4 h / Heating 5: 49 percent / Br2, triphenylphosphite / CH2Cl2 / 3 h / Ambient temperature 6: 1.) Mg; 2.) CuBr / 1.) THF, 2h, reflux; 2.) THF, 2h, reflux 7: 91 percent / H2O, p-TosOH / methanol View Scheme
参考文献
Liebigs Annalen der Chemie, , p. 877 - 880
反应条件
1: 49 percent / Br2, triphenylphosphite / CH2Cl2 / 3 h / Ambient temperature 2: 1.) Mg; 2.) CuBr / 1.) THF, 2h, reflux; 2.) THF, 2h, reflux 3: 91 percent / H2O, p-TosOH / methanol View Scheme
参考文献
Liebigs Annalen der Chemie, , p. 877 - 880
反应条件
1: 1.) Mg; 2.) CuBr / 1.) THF, 2h, reflux; 2.) THF, 2h, reflux 2: 91 percent / H2O, p-TosOH / methanol View Scheme
参考文献
Liebigs Annalen der Chemie, , p. 877 - 880
反应条件
1: 87 percent / LiAlH4, MeOH / tetrahydrofuran / 4 h / Heating 2: 49 percent / Br2, triphenylphosphite / CH2Cl2 / 3 h / Ambient temperature 3: 1.) Mg; 2.) CuBr / 1.) THF, 2h, reflux; 2.) THF, 2h, reflux 4: 91 percent / H2O, p-TosOH / methanol View Scheme
参考文献
Liebigs Annalen der Chemie, , p. 877 - 880
