2-氯-1-(5-氟-2-吡啶)乙酮合成路线 (共 1 条)
反应条件
1: 2-bromo-5-fluoropyridine With isopropylmagnesium chloride in tetrahydrofuran T=20°C; 2.41667 h; 2: chloroacetic acid N-methyl-N-methoxy-amide in tetrahydrofuran 3: With hydrogenchloride in tetrahydrofuran; water Cooling with ice;
参考文献
MERCK SHARP and DOHME CORP.; GUO, Liangqin; HAGMANN, William, K.; HE, Shuwen; LAI, Zhong; LIU, Jian; NARGUND, Ravi, P.; SHAH, Shrenik, K.; TRUONG, Quang, T.
Patent: WO2011/88025 A1, 2011 ;
Location in patent: Page/Page column 48-49 ;