2-吡啶-2-基-丙二酸二叔丁酯合成路线 （共 2 条）
反应条件
1: 2-picoline With n-butyllithium; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=-78°C; 1 h; 2: di-tert-butyl dicarbonate in tetrahydrofuran T=-78 - 20°C; 2 h;
参考文献
GRÜNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; LESCH, Bernhard
Patent: WO2013/13815 A1, 2013 ;
Location in patent: Page/Page column 125 ;
WO 2013/013815 A1
反应条件
1: 2-picoline With lithium diisopropyl amide in tetrahydrofuran; hexane T=-78°C; 0.75 h; 2: di-tert-butyl dicarbonate in tetrahydrofuran; hexane T=-78 - 20°C; 2 h;
参考文献
Augustine, John Kallikat; Arthoba Naik; Vairaperumal, Veeramani; Narasimhan, Sharmila
Tetrahedron, 2009 , vol. 65, # 1 p. 134 - 138
