您好，欢迎来到魔法化学网！
合作交流
|
服务时间(9:30-18:00)
百科
百科
▼
百科
资讯
搜索
结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
首页
化合物百科
价格行情
资讯
化工导航
实验室工具
搜索
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
110481-26-0
合成路线
（共 5 条）
110481-26-0
→
反应条件
139110-80-8
扎那米韦
反应条件
1: triphenylphosphine hydrobromide / acetonitrile / 5 h / 0 - 55 °C / Inert atmosphere 2: copper(I) bromide / dichloromethane / 3 h / Reflux; Inert atmosphere 3: sulfuric acid; acetic acid / 12 h / 0 - 20 °C / Inert atmosphere 4: trimethylsilylazide / tert-butyl alcohol / 10 h / Reflux; Inert atmosphere 5: hydrogen / ethanol / 15 h / 20 °C / 760.05 Torr / Inert atmosphere 6: tetrahydrofuran / 29 h / 50 °C / Inert atmosphere 7: methanol; sodium methylate / 1 h / 20 °C / Inert atmosphere 8: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C / Inert atmosphere View Scheme
参考文献
Nitabaru, Tatsuya; Kumagai, Naoya; Shibasaki, Masakatsu
Angewandte Chemie - International Edition, 2012 , vol. 51, # 7 p. 1644 - 1647
110481-26-0
→
反应条件
130525-58-5
5-乙酰氨基-7,8,9-O-三乙酰基-2,6-脱水-4-叠氮-3,4,5-三脱氧-D-甘油-D-半乳-2-壬烯酸甲酯
反应条件
1: triphenylphosphine hydrobromide / acetonitrile / 5 h / 0 - 55 °C / Inert atmosphere 2: copper(I) bromide / dichloromethane / 3 h / Reflux; Inert atmosphere 3: sulfuric acid; acetic acid / 12 h / 0 - 20 °C / Inert atmosphere 4: trimethylsilylazide / tert-butyl alcohol / 10 h / Reflux; Inert atmosphere View Scheme
参考文献
Nitabaru, Tatsuya; Kumagai, Naoya; Shibasaki, Masakatsu
Angewandte Chemie - International Edition, 2012 , vol. 51, # 7 p. 1644 - 1647
110481-26-0
→
反应条件
139110-70-6
扎那米韦
反应条件
1: triphenylphosphine hydrobromide / acetonitrile / 5 h / 0 - 55 °C / Inert atmosphere 2: copper(I) bromide / dichloromethane / 3 h / Reflux; Inert atmosphere 3: sulfuric acid; acetic acid / 12 h / 0 - 20 °C / Inert atmosphere 4: trimethylsilylazide / tert-butyl alcohol / 10 h / Reflux; Inert atmosphere 5: hydrogen / ethanol / 15 h / 20 °C / 760.05 Torr / Inert atmosphere View Scheme
参考文献
Nitabaru, Tatsuya; Kumagai, Naoya; Shibasaki, Masakatsu
Angewandte Chemie - International Edition, 2012 , vol. 51, # 7 p. 1644 - 1647
110481-26-0
→
反应条件
78850-37-0
甲基(3aR,4R,7aR)-2-甲基-4-[(1S,2R)-1,2,3-三乙酰氧基丙基]-3a,7a-二氢-4H-吡喃并[3,4-d][1,3]恶唑-6-羧酸酯
反应条件
1: triphenylphosphine hydrobromide / acetonitrile / 5 h / 0 - 55 °C / Inert atmosphere 2: copper(I) bromide / dichloromethane / 3 h / Reflux; Inert atmosphere 3: sulfuric acid; acetic acid / 12 h / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Nitabaru, Tatsuya; Kumagai, Naoya; Shibasaki, Masakatsu
Angewandte Chemie - International Edition, 2012 , vol. 51, # 7 p. 1644 - 1647
110481-26-0
→
反应条件
107020-87-1
反应条件
With trimethylsilyl trifluoromethanesulfonate in acetonitrile 5 h; Ambient temperature;
参考文献
Driguez, Pierre-Alexandre; Barrere, Beatrice; Quash, Gerard; Doutheau, Alain Carbohydrate Research, 1994 , vol. 262, # 2 p. 297 - 310
