1,4-二氢-4-氧代噻吩并[2,3-d]嘧啶-5-羧酸合成路线 （共 2 条）
反应条件
lithium hydroxide hydrate in methanol; water T=8°C; Inert atmosphere;
参考文献
Hill, Pamela J.; Abibi, Ayome; Albert, Robert; Andrews, Beth; Gagnon, Moriah M.; Gao, Ning; Grebe, Tyler; Hajec, Laurel I.; Huang, Jian; Livchak, Stephania; Lahiri, Sushmita D.; McKinney, David C.; Thresher, Jason; Wang, Hongming; Olivier, Nelson; Buurman, Ed T.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 18 p. 7278 - 7288
反应条件
1: ethanol / 70 h / |Inert atmosphere; |Reflux 2: lithium hydroxide hydrate / water; methanol / 8 °C / |Inert atmosphere View Scheme
参考文献
Hill, Pamela J.; Abibi, Ayome; Albert, Robert; Andrews, Beth; Gagnon, Moriah M.; Gao, Ning; Grebe, Tyler; Hajec, Laurel I.; Huang, Jian; Livchak, Stephania; Lahiri, Sushmita D.; McKinney, David C.; Thresher, Jason; Wang, Hongming; Olivier, Nelson; Buurman, Ed T.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 18 p. 7278 - 7288
