1-[(4-硝基苯)甲基]吡唑合成路线 （共 6 条）
反应条件
potassium carbonate in acetonitrile 58 h; Irradiation;
参考文献
Beugelmans, Rene; Lechevalier, Andre
Tetrahedron Letters, 1986 , vol. 27, # 51 p. 6209 - 6212
反应条件
bis(η3-allyl-μ-chloropalladium(II)); CPME; SSPhos; caesium carbonate in water T=100°C; Suzuki-Miyaura Coupling; 24 h; Inert atmosphere;
参考文献
Molander, Gary A.; Ryu, Daweon; Hosseini-Sarvari, Mona; Devulapally, Rammohan; Seapy, Dave G.
Journal of Organic Chemistry, 2013 , vol. 78, # 13 p. 6648 - 6656
反应条件
bis(η3-allyl-μ-chloropalladium(II)); CPME; SSPhos; caesium carbonate in water T=100°C; Suzuki-Miyaura Coupling; 24 h; Inert atmosphere;
参考文献
Molander, Gary A.; Ryu, Daweon; Hosseini-Sarvari, Mona; Devulapally, Rammohan; Seapy, Dave G.
Journal of Organic Chemistry, 2013 , vol. 78, # 13 p. 6648 - 6656
反应条件
1: [3,2-c]pyrazole With tetrabutylammomium bromide; potassium carbonate T=20°C; Metallation; 1 h; 2: 1-bromomethyl-4-nitro-benzene T=20°C; Substitution; 24 h; Sonication;
参考文献
TETRA DISCOVERY PARTNERS, LLC.; GURNEY, Mark, E.; HAGEN, Timothy, J.; MO, Xuesheng; VELLEKOOP, A.; ROMERO, Donna, L.; CAMPBELL, Robert, F.; WALKER, Joel, R.; ZHU, Lei
Patent: WO2014/66659 A1, 2014 ;
Location in patent: Paragraph 0824 ;
反应条件
hydrogen; palladium on activated charcoal in ethanol P=760 Torr; Ambient temperature;
参考文献
Biagi; Dell'Omodarme; Ferretti; Giorgi; Livi; Scartoni
Farmaco, 1992 , vol. 47, # 3 p. 335 - 344
反应条件
1: 95 percent / H2 / 5percent Pd/C / aq. ethanol / 760 Torr / Ambient temperature
2: 85 percent / 3M H2SO4, NaNO2 / H2O / 0.83 h / 0 - 85 °C
View Scheme
参考文献
Biagi; Dell'Omodarme; Ferretti; Giorgi; Livi; Scartoni
Farmaco, 1992 , vol. 47, # 3 p. 335 - 344
