1.1: 3.52 g / K2CO3 / dimethylformamide / 2.5 h / 80 °C 2.1: 70 percent / ethylenediamine / 6 h / 50 °C 3.1: 95 percent / p-toluenesulfonyl chloride; pyridine / 20 h / 20 °C 4.1: 60 percent / diiodomethane; isoamyl nitrite / 0.75 h / 100 °C 5.1: Pd(PhCN)2Cl2; Et3N / acetonitrile / 20 h / 110 °C 5.2: 50 percent / NH3; methanol / 14 h / 120 °C 6.1: 79 percent / Amberlite IRA 900 fluoride-form / toluene / 6 h / Heating View Scheme

Multi-step reaction with 5 steps 1: 3.52 g / K2CO3 / dimethylformamide / 2.5 h / 80 °C2: 70 percent / ethylenediamine / 6 h / 50 °C3: 95 percent / p-toluenesulfonyl chloride; pyridine / 20 h / 20 °C4: 60 percent / diiodomethane; isoamyl nitrite / 0.75 h / 100 °C5: Pd(PhCN)2Cl2; Et3N / acetonitrile / 20 h / 110 °C