(R)-(+)-3-溴异丁酸甲酯合成路线 （共 7 条）
反应条件
pyridine; carbon tetrabromide; triphenylphosphine in tetrahydrofuran 1.) from 5 deg C to 10 deg C, 1 h, 2.) 25 deg C, 2 h;
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 26, # 2.2 p. 364 - 369
Zhurnal Organicheskoi Khimii, , vol. 26, # 2 p. 425 - 432
反应条件
1-methyl-pyrrolidin-2-one; lithium bromide
参考文献
Tetrahedron Asymmetry, , vol. 9, # 7 p. 1131 - 1135
反应条件
N-bromosuccinmide; triphenylphosphine
参考文献
Tetrahedron Letters, , vol. 28, # 3 p. 337 - 340
反应条件
1: With methanesulfonyl chloride; triethylamine in dichloromethane T=-10°C; Inert atmosphere; 2: With lithium bromide in acetone 12 h; Inert atmosphereReflux; stereoselective reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 354, # 8 p. 1519 - 1528
反应条件
1: 75 percent / K2CO3 / methanol / 1 h / 5 - 10 °C 2: 77 percent / tetrabromomethane, pyridine, triphenylphosphine / tetrahydrofuran / 1.) from 5 deg C to 10 deg C, 1 h, 2.) 25 deg C, 2 h View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 26, # 2.2 p. 364 - 369
Zhurnal Organicheskoi Khimii, , vol. 26, # 2 p. 425 - 432
反应条件
Bradyrhizobium japonicum haloalkane dehalogenase T=21°C; pH=8.2; Tris sulfate bufferResolution of racemateEnzymatic reaction; enantioselective reaction;
参考文献
Angewandte Chemie - International Edition, , vol. 49, # 35 p. 6111 - 6115
反应条件
Yield given. Multistep reaction;
参考文献
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , vol. 37, # 11 p. 2387
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 11 p. 2647 - 2648
