(1S,2R,3S,5R)-3-(苄氧基)-2-[(苄氧基)甲基]-6-氧杂二环[3.1.0]己烷合成路线 （共 15 条）
反应条件
1: 60 percent / LiH / dimethylformamide / 2 h / 125 °C 2: 82 percent / TEA, DMAP / CH2Cl2 3: Dess-Martin reagent, t-BuOH / CH2Cl2 4: Zn, TiCl4 / tetrahydrofuran; CH2Cl2 5: 92 percent / aq. HCl / tetrahydrofuran; methanol / 55 °C View Scheme
参考文献
Bisacchi; Chao; Bachard; Daris; Innaimo; Jacobs; Kocy; Lapointe; Martel; Merchant; Slusarchyk; Sundeen; Young; Colonno; Zahler
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 2 p. 127 - 132
反应条件
1: 60 percent / LiH / dimethylformamide / 2 h / 125 °C 2: 82 percent / TEA, DMAP / CH2Cl2 3: Dess-Martin reagent, t-BuOH / CH2Cl2 4: Zn, TiCl4 / tetrahydrofuran; CH2Cl2 5: 92 percent / aq. HCl / tetrahydrofuran; methanol / 55 °C 6: 89 percent / BCl3 / CH2Cl2 / -78 °C View Scheme
参考文献
Bisacchi; Chao; Bachard; Daris; Innaimo; Jacobs; Kocy; Lapointe; Martel; Merchant; Slusarchyk; Sundeen; Young; Colonno; Zahler
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 2 p. 127 - 132
反应条件
lithium hydride in N,N-dimethyl-formamide T=125°C; 2 h;
参考文献
Bisacchi; Chao; Bachard; Daris; Innaimo; Jacobs; Kocy; Lapointe; Martel; Merchant; Slusarchyk; Sundeen; Young; Colonno; Zahler
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 2 p. 127 - 132
反应条件
1: 60 percent / LiH / dimethylformamide / 2 h / 125 °C 2: 82 percent / TEA, DMAP / CH2Cl2 3: Dess-Martin reagent, t-BuOH / CH2Cl2 4: Zn, TiCl4 / tetrahydrofuran; CH2Cl2 View Scheme
参考文献
Bisacchi; Chao; Bachard; Daris; Innaimo; Jacobs; Kocy; Lapointe; Martel; Merchant; Slusarchyk; Sundeen; Young; Colonno; Zahler
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 2 p. 127 - 132
反应条件
1: 60 percent / LiH / dimethylformamide / 2 h / 125 °C 2: 82 percent / TEA, DMAP / CH2Cl2 View Scheme
参考文献
Bisacchi; Chao; Bachard; Daris; Innaimo; Jacobs; Kocy; Lapointe; Martel; Merchant; Slusarchyk; Sundeen; Young; Colonno; Zahler
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 2 p. 127 - 132
