1: 87 percent / lithium iodide hydrate / dimethylformamide / 1 h / Heating 2: 94 percent / H2 / Pt-oxide / acetic acid / 1 h 3: 62 percent / K2CO3 / 16 h / Ambient temperature 4: 6 h / 60 °C 5: 15 percent HCl / 1) 16 h, r.t.; 2) 30 min, 60 deg C 6: 98 percent / H2 / Pd/C / acetic acid / 1 h / Ambient temperature View Scheme

Multi-step reaction with 3 steps 1: 92 percent / CrO3, pyridine / CH2Cl2 / 0.25 h / Ambient temperature2: 60 percent / hydrazine hydrate, glacial acetic acid / ethanol / 1.5 h / Ambient temperature3: 99 percent / 4-methylmorpholine / diethyl ether / 20 h / Ambient temperature  

Multi-step reaction with 2 steps 1: 60 percent / hydrazine hydrate, glacial acetic acid / ethanol / 1.5 h / Ambient temperature2: 99 percent / 4-methylmorpholine / diethyl ether / 20 h / Ambient temperature  

Multi-step reaction with 4 steps 1: 53 percent / VO(acac)2, tert-butylhydroperoxide / benzene / 48 h / 40 °C2: 92 percent / CrO3, pyridine / CH2Cl2 / 0.25 h / Ambient temperature3: 60 percent / hydrazine hydrate, glacial acetic acid / ethanol / 1.5 h / Ambient temperature4: 99 percent / 4-methylmorpholine / diethyl ether / 20 h / Ambient temperature  

T=200°C; 1 h;   

With  lithium iodide in  N,N-dimethyl-formamide 1 h;  Heating;   

Multi-step reaction with 3 steps 1: 87 percent / lithium iodide hydrate / dimethylformamide / 1 h / Heating2: 94 percent / H2 / Pt-oxide / acetic acid / 1 h3: 62 percent / K2CO3 / 16 h / Ambient temperature  

Multi-step reaction with 4 steps 1: 87 percent / lithium iodide hydrate / dimethylformamide / 1 h / Heating2: 94 percent / H2 / Pt-oxide / acetic acid / 1 h3: 62 percent / K2CO3 / 16 h / Ambient temperature4: 6 h / 60 °C  

Multi-step reaction with 5 steps 1: 87 percent / lithium iodide hydrate / dimethylformamide / 1 h / Heating2: 94 percent / H2 / Pt-oxide / acetic acid / 1 h3: 62 percent / K2CO3 / 16 h / Ambient temperature4: 6 h / 60 °C5: 15 percent HCl / 1) 16 h, r.t.; 2) 30 min, 60 deg C