2-噁-3-氮杂双环[2.2.2]-5-辛烯-3-羧酸叔丁酯合成路线 （共 5 条）
反应条件
dihydrogen peroxide; copper(l) chloride in 1,2-dichloro-ethane; acetonitrile T=20°C; Diels-Alder reaction;
参考文献
Kalita, Biswajit; Nicholas, Kenneth M.
Tetrahedron Letters, 2005 , vol. 46, # 9 p. 1451 - 1453
反应条件
1: 55 percent / hydroxylamine hydrochloride; NaHCO3 / CH2Cl2; H2O / 0 - 5 °C 2: 100 percent / aq. H2O2 / CuCl / 1,2-dichloro-ethane; acetonitrile / 20 °C View Scheme
参考文献
Kalita, Biswajit; Nicholas, Kenneth M.
Tetrahedron Letters, 2005 , vol. 46, # 9 p. 1451 - 1453
反应条件
[{(η5-C5Me5)RhCl}2(μ-Cl)2]; caesium acetate; copper(l) chloride; 2,2,2-trimethylacetic acid in ethanol; acetone T=20°C; Diels-Alder Cycloaddition; 48 h;
参考文献
Yang, Wei; Sun, Jiaqiong; Xu, Xianxiu; Zhang, Qian; Liu, Qun
Chemical Communications, 2014 , vol. 50, # 34 p. 4420 - 4422
反应条件
1: 2-oxa-3-azabicyclo[2.2.2]oct-5-ene With anhydrous lithium acetate; 2,2-Dimethyl-1,3-dioxan-5-one in 1,2-dichloro-ethane T=85°C; 22 h; 2: With hydrogenchloride in water; 1,2-dichloro-ethane 3: di-tert-butyl dicarbonate With sodium hydroxide in water; 1,2-dichloro-ethane Reactivity; SolventTemperatureTimeReagent/catalyst;
参考文献
Galvani, Gilles; Calvet, Geraldine; Blanchard, Nicolas; Kouklovsky, Cyrille
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 6 p. 1063 - 1070
反应条件
1: (+/-)-2-Oxa-3-azabicyclo[2.2.2]oct-5-ene hydrochloride With [1,3]-dithiolane-2-carbaldehyde in isopropyl alcohol T=40°C; 30 h; 2: With hydrogenchloride in water 3: di-tert-butyl dicarbonate With sodium hydroxide in water Reactivity; TemperatureTimeReagent/catalyst;
参考文献
Galvani, Gilles; Calvet, Geraldine; Blanchard, Nicolas; Kouklovsky, Cyrille
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 6 p. 1063 - 1070
