5-氯-2-(氯甲基)-1,3-苯并噻唑合成路线 （共 6 条）
反应条件
1: With triethylamine in toluene T=20 - 105°C; Inert atmosphere; 2: With water; sodium hydrogencarbonate in toluene
参考文献
Mutabilis
Patent: EP2141164 A1, 2010 ;
Location in patent: Page/Page column 37-38 ;
参考文献
BIOTA EUROPE LTD.
Patent: US2010/298388 A1, 2010 ;
Location in patent: Page/Page column 7 ;
参考文献
PROLYSIS LTD
Patent: WO2007/107758 A1, 2007 ;
Location in patent: Page/Page column 88-89 ;
WO 2007/107758 A1
参考文献
Kotani, Takayuki; Ishii, Akira; Nagaki, Yasuhiro; Toyomaki, Yoshio; Yago, Hisashi; Suehiro, Seishi; Okukado, Nobuhisa; Okamoto, Kaoru
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 2 p. 297 - 304
反应条件
sodium bromide in N,N-dimethyl-formamide
参考文献
Kotani, Takayuki; Ishii, Akira; Nagaki, Yasuhiro; Toyomaki, Yoshio; Yago, Hisashi; Suehiro, Seishi; Okukado, Nobuhisa; Okamoto, Kaoru
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 2 p. 297 - 304
反应条件
ammonium hydroxide; tetra-(n-butyl)ammonium iodide in tetrahydrofuran; water
T=60°C;
参考文献
Mutabilis
Patent: EP2141164 A1, 2010 ;
Location in patent: Page/Page column 37-38 ;
