1: 1.) LiOH; 2.) AcOH / 1.) EtOH, r.t.; 2.) r.t. 2: 80 percent / TFA / Ambient temperature 3: 73 percent / p-TsOH / toluene View Scheme

1: 1.) LiOH; 2.) AcOH / 1.) EtOH, r.t.; 2.) r.t. 2: 80 percent / TFA / Ambient temperature View Scheme

Multi-step reaction with 3 steps 1: Na2CO3 / dimethylformamide / 70 °C2: NaH / dimethylformamide / Ambient temperature  

Multi-step reaction with 4 steps 1: 56.4 percent / 1) sodium hydride / 1) DMF, room temperature, 1 h, 2) room temperature, 3 h2: 99.8 percent / H2 / Raney Ni / acetic acid / 3 h3: NaNO2, HOAc / acetic anhydride / 4 h / 0 °C4: CCl4 / 5 h / Heating  

Multi-step reaction with 3 steps 1: 99.8 percent / H2 / Raney Ni / acetic acid / 3 h2: NaNO2, HOAc / acetic anhydride / 4 h / 0 °C3: CCl4 / 5 h / Heating  

Multi-step reaction with 2 steps 1: NaNO2, HOAc / acetic anhydride / 4 h / 0 °C2: CCl4 / 5 h / Heating