Nα-[(9H-芴-9-基甲氧基)羰基]-L-丝氨酸叔丁酯合成路线 （共 10 条）
反应条件
1H-imidazole in dichloromethane Iodination; 0.5 h; Heating;
参考文献
Organic letters, , vol. 2, # 15 p. 2265 - 2267
反应条件
in cyclohexane; ethyl acetate
18 h; Inert atmosphere;
参考文献
Knerr, Patrick J.; Van Der Donk, Wilfred A.
Journal of the American Chemical Society, 2012 , vol. 134, # 18 p. 7648 - 7651
反应条件
tri-iso-propylsilane; trifluoroacetic acid in dichloromethane
T=20°C; 1 h;
参考文献
Rothman, Deborah M.; Vazquez, M. Eugenio; Vogel, Elizabeth M.; Imperiali, Barbara
Journal of Organic Chemistry, 2003 , vol. 68, # 17 p. 6795 - 6798
反应条件
sodium carbonate in 1,4-dioxane; water
T=20°C; 48 h;
参考文献
Liu, Hongqiang; Pattabiraman, Vijaya R.; Vederas, John C.
Organic Letters, 2007 , vol. 9, # 21 p. 4211 - 4214
反应条件
1: tert-butyl alcohol With dicyclohexyl-carbodiimide; copper(l) chloride
T=20°C; 72 h;
2: FMOC-SER in dichloromethane
T=20°C; 2 h;
参考文献
Pillion, Dany; Deraet, Maud; Holleran, Brian J.; Escher, Emanuel
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2200 - 2209
反应条件
1: 100 percent / CH2Cl2; cyclohexane / 40 °C
2: 29 percent / H2; acetic acid / Pd/C / ethanol
View Scheme
参考文献
Ginisty, Maryon; Gravier-Pelletier, Christine; Le Merrer, Yves
Tetrahedron Asymmetry, 2006 , vol. 17, # 1 p. 142 - 150
反应条件
1: 78 percent / CH2Cl2; tetrahydrofuran / 20 °C
2: 99 percent / trifluoroacetic acid; triisopropylsilane / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Rothman, Deborah M.; Vazquez, M. Eugenio; Vogel, Elizabeth M.; Imperiali, Barbara
Journal of Organic Chemistry, 2003 , vol. 68, # 17 p. 6795 - 6798
反应条件
1: NEt3 / CH2Cl2 / 30 h
2: conc.H2SO4 / CH2Cl2 / 240 h
3: N2H4*H2O / ethanol / 0.5 h
View Scheme
参考文献
Paulsen, Hans; Adermann, Knut
Liebigs Annalen der Chemie, 1989 , p. 751 - 770
反应条件
1: conc.H2SO4 / CH2Cl2 / 240 h
2: N2H4*H2O / ethanol / 0.5 h
View Scheme
参考文献
Paulsen, Hans; Adermann, Knut
Liebigs Annalen der Chemie, 1989 , p. 751 - 770
反应条件
in ethyl acetate
24 h; Ambient temperature;
参考文献
Thierry, Josiane; Yue, Chongwei; Potier, Pierre
Tetrahedron Letters, 1998 , vol. 39, # 12 p. 1557 - 1560
