5,6,7,8-四氢萘-1-羰酰氯合成路线 （共 7 条）
参考文献
Zhurnal Obshchei Khimii, , vol. 15, p. 940,943
Chem.Abstr., , p. 6453
反应条件
1: (S)-1-azabicyclo[2.2.2]oct-3-ylamine dihydrochloride With sodium hydroxide; water in toluene T=60°C; 1 h; 2: 5,6,7,8-tetrahydronaphthylene-1-carboxylic acid chloride in toluene T=60°C; 1.5 h; Product distribution / selectivity;
参考文献
Rossetto, Pierluigi; MacDonald, Peter; Bigatti, Ettore; Banfi, Gaia; Tentorio, Dario
Patent: US2008/200681 A1, 2008 ;
Location in patent: Page/Page column 11 ;
反应条件
in toluene T=40 - 65°C; Inert atmosphere;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; KATKAM, Srinivas; SAGYAM, Rajeshwar Reddy; SUNKARA, Vishnuvardhan; MUNAGALA, Sridhar; MUTTAVARAPU, Murali Mohan
Patent: WO2010/56656 A2, 2010 ;
Location in patent: Page/Page column 22 ;
反应条件
diethyl ether; cadmium (II) chloride; benzene
参考文献
Hunsberger et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 3294,3299
Full Text Show Details
Granger; Orzalesi
Bulletin de la Societe Chimique de France, 1958 , p. 986,989
反应条件
1.1: 13.14 g / toluene / 0 °C 2.1: BuLi / tetrahydrofuran; hexane / 0.67 h / -70 - -65 °C 2.2: 92 percent / tetrahydrofuran; hexane / -70 - 20 °C 3.1: 77 percent / aq. HCl / 0.75 h 4.1: 63 percent / 45 h / 110 - 115 °C View Scheme
参考文献
Clark; Miller; Berger; Repke; Weinhardt; Kowalczyk; Eglen; Bonhaus; Lee; Michel; Smith; Wong
Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2645 - 2657
反应条件
1.1: 13.14 g / toluene / 0 °C 2.1: BuLi / tetrahydrofuran; hexane / 0.67 h / -70 - -65 °C 2.2: 92 percent / tetrahydrofuran; hexane / -70 - 20 °C 3.1: 77 percent / aq. HCl / 0.75 h View Scheme
参考文献
Kowalczyk, Bruce A.
Synthesis, 2000 , # 8 p. 1113 - 1116
反应条件
Pd-BaSO4; BaSO4-catalyst
Hydrogenation;
参考文献
Hunsberger et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 3294,3299
