1: 1.) CF3COOH; 2.) NaIO4; 3.) MeONa 2: 82 percent / 20 percent Pd(OH)2/C / ethanol; cyclohexene / 2.5 h / Heating 3: 90 percent / 4-dimethylaminopyridine / pyridine / 16 h / 20 °C 4: 1.) hexamethyldisilazane; 2.) CF3SO2SiMe3 / 1.) pyridine, reflux, 4 h; 2.) 1,2-dichloroethane, 20 deg C, 16 h 5: 72 percent / ammonia / methanol / 48 h / 20 °C View Scheme

Multi-step reaction with 3 steps 1: 1.) CF3COOH; 2.) NaIO4; 3.) MeONa2: 82 percent / 20 percent Pd(OH)2/C / ethanol; cyclohexene / 2.5 h / Heating3: 90 percent / 4-dimethylaminopyridine / pyridine / 16 h / 20 °C  

Multi-step reaction with 4 steps 1: 1.) CF3COOH; 2.) NaIO4; 3.) MeONa2: 82 percent / 20 percent Pd(OH)2/C / ethanol; cyclohexene / 2.5 h / Heating3: 90 percent / 4-dimethylaminopyridine / pyridine / 16 h / 20 °C4: 1.) hexamethyldisilazane; 2.) CF3SO2SiMe3 / 1.) pyridine, reflux, 4 h; 2.) 1,2-dichloroethane, 20 deg C, 16 h  

Multi-step reaction with 2 steps 1: 1.) CF3COOH; 2.) NaIO4; 3.) MeONa2: 82 percent / 20 percent Pd(OH)2/C / ethanol; cyclohexene / 2.5 h / Heating