2,4-二甲氧基-5-嘧啶羧酸合成路线 (共 4 条)
反应条件
sodium chlorite; sodium dihydrogenphosphate; water in tert-butyl alcohol T=0 - 25°C;
参考文献
Glaxo Group Limited
Patent: WO2009/43883 A1, 2009 ;
Location in patent: Page/Page column 58-59 ;
WO 2009/043883 A1
反应条件
tetrahydrofuran; diethyl ether
参考文献
Langley
Journal of the American Chemical Society, 1956 , vol. 78, p. 2136,2140
参考文献
Langley
Journal of the American Chemical Society, 1956 , vol. 78, p. 2136,2140
反应条件
1: 2,4-dimethoxy-pyrimidine-5-carboxylic acid With 1,1'-carbonyldiimidazole in N,N-dimethyl-formamide T=0 - 20°C; 5 h; 2: With triethylamine; 1,1'-carbonyldiimidazole in N,N-dimethyl-formamide 3: methanol 2 h; Heating / reflux;
参考文献
Glaxo Group Limited
Patent: WO2009/43883 A1, 2009 ;
Location in patent: Page/Page column 59 ;
WO 2009/043883 A1