4-甲基-1,2,3,4-四氢异喹啉合成路线 （共 10 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 24 h; Heating;
参考文献
Grunewald; Sall; Monn
Journal of Medicinal Chemistry, 1988 , vol. 31, # 2 p. 433 - 444
反应条件
sodium tetrahydroborate in methanol 1 h; Heating;
参考文献
Olefirowicz, Edward M.; Eliel, Ernest L.
Journal of Organic Chemistry, 1997 , vol. 62, # 26 p. 9154 - 9158
反应条件
PPA in chloroform T=180°C; 2 h;
参考文献
Euerby, Melvin R.; Waigh, Roger D.
Journal of Chemical Research, Miniprint, 1987 , # 2 p. 554 - 575
反应条件
1: 77.6 percent / Et3N / tetrahydrofuran / 24 h / Ambient temperature 2: 64.3 percent / polyphosphoric acid / 0.33 h / 140 °C 3: 47.4 percent / LiAlH4 / tetrahydrofuran / 24 h / Heating View Scheme
参考文献
Blatt, Lawrence M.; Andrews, Steven W.; Condroski, Kevin R.; Doherty, George A.; Jiang, Yutong; Josey, John A.; Kennedy, April L.; Madduru, Machender R.; Stengel, Peter J.; Wenglowsky, Steven M.; Woodard, Benjamin T.; Woodard, Laura
Patent: US2005/267018 A1, 2005 ;
US 20050267018 A1
反应条件
1: 64.3 percent / polyphosphoric acid / 0.33 h / 140 °C 2: 47.4 percent / LiAlH4 / tetrahydrofuran / 24 h / Heating View Scheme
参考文献
Grunewald; Sall; Monn
Journal of Medicinal Chemistry, 1988 , vol. 31, # 2 p. 433 - 444
反应条件
1: Ni 2: 1.) 1.0 M lithium triethylborohydride; 2.) methanol / 1.) THF, RT. 0.5 h View Scheme
参考文献
Blough; Carroll
Tetrahedron Letters, 1993 , vol. 34, # 45 p. 7239 - 7242
反应条件
1: 2.) NaBH4 / 1.) ethanol, 24 h, 2.) overnight 2: 61 percent / PPA / CHCl3 / 2 h / 180 °C View Scheme
参考文献
Euerby, Melvin R.; Waigh, Roger D.
Journal of Chemical Research, Miniprint, 1987 , # 2 p. 554 - 575
反应条件
methanol; lithium triethylborohydride 1.) THF, RT. 0.5 h; Yield given. Multistep reaction;
参考文献
Blough; Carroll
Tetrahedron Letters, 1993 , vol. 34, # 45 p. 7239 - 7242
反应条件
1: 97.6 percent / 10percent aq. NaOH
2: 5.2 percent / ethanol / 72 h / 28 °C / culture of fungus Cunninghamella elegans Lendner
View Scheme
参考文献
Canfield, Lesley M.; Crabb, Trevor A.
Journal of Chemical Research, Miniprint, 1997 , # 11 p. 2401 - 2416
反应条件
oxygen; acetone-oxime in acetonitrile
T=40°C; P=860.3 Torr; 6 h;
参考文献
Shimizu, Masao; Orita, Hideo; Hayakawa, Takashi; Suzuki, Kunio; Takehira, Katsuomi
Heterocycles, 1995 , vol. 41, # 4 p. 773 - 780
