2-氯-1-(2,4,6-三羟基苯基)乙酮合成路线 （共 6 条）
反应条件
1: With hydrogenchloride; zinc(II) chloride in diethyl ether T=0°C; 0.25 h; 2: With hydrogenchloride T=100°C; 1 h;
参考文献
Boumendjel, Ahcene; Beney, Chantal; Deka, Nabajyoti; Mariotte, Anne-Marie; Lawson, Martin Ata; Trompier, Doriane; Baubichon-Cortay, Helene; Di Pietro, Attilio
Chemical and Pharmaceutical Bulletin, 2002 , vol. 50, # 6 p. 854 - 856
反应条件
hydrogenchloride; diethyl ether; zinc(II) chloride Behandeln des Reaktionsgemisches mit einer Loesung von Chloracetonitril in Aether und Erwaermen des Reaktionsprodukts mit Wasser;
参考文献
Haudecoeur, Romain; Ahmed-Belkacem, Abdelhakim; Yi, Wei; Fortune, Antoine; Brillet, Rozenn; Belle, Catherine; Nicolle, Edwige; Pallier, Coralie; Pawlotsky, Jean-Michel; Boumendjel, Ahcene
Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5395 - 5402
反应条件
1: 71 percent / sodium methoxide / methanol / 2 h / Heating 2: 7 percent / conc. HCl / acetic acid / 5 h / 20 °C View Scheme
参考文献
Haudecoeur, Romain; Ahmed-Belkacem, Abdelhakim; Yi, Wei; Fortune, Antoine; Brillet, Rozenn; Belle, Catherine; Nicolle, Edwige; Pallier, Coralie; Pawlotsky, Jean-Michel; Boumendjel, Ahcene
Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5395 - 5402
反应条件
1: With sodium hydroxide in ethanol; water 2: With hydrogenchloride Further stages.;
参考文献
Zheng, Xing; Meng, Wei-Dong; Qing, Feng-Ling
Tetrahedron Letters, 2004 , vol. 45, # 43 p. 8083 - 8085
反应条件
sodium acetate in methanol 2 h; Reflux;
参考文献
Lee, Chong-Yew; Chew, Eng-Hui; Go, Mei-Lin
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 7 p. 2957 - 2971
反应条件
1: With sodium hydroxide in ethanol
2: With hydrogenchloride in ethanol
参考文献
Zheng, Xing; Cao, Jian-Guo; Meng, Wei-Dong; Qing, Feng-Ling
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3423 - 3427
