8-氯-4-羟基-7-甲氧基-2-(3-三氟甲基-1H-吡唑-1-基)-喹啉合成路线 （共 2 条）
反应条件
1: trichlorophosphate / 16 h / Reflux 2: 6 h / 120 °C 3: potassium tert-butylate; water / dimethyl sulfoxide / 4 h / 140 °C View Scheme
参考文献
IDENIX PHARMACEUTICALS, INC.; PARSY, Christophe Claude; ALEXANDRE, Francois-Rene; LEROY, Frederic; CONVARD, Thierry; SURLERAUX, Dominique
Patent: WO2011/17389 A1, 2011 ;
WO 2011/017389 A1
反应条件
1: 6 h / 120 °C 2: potassium tert-butylate; water / dimethyl sulfoxide / 4 h / 140 °C View Scheme
参考文献
IDENIX PHARMACEUTICALS, INC.; PARSY, Christophe Claude; ALEXANDRE, Francois-Rene; LEROY, Frederic; CONVARD, Thierry; SURLERAUX, Dominique
Patent: WO2011/17389 A1, 2011 ;
WO 2011/017389 A1
