2-氯-4,5-二氟苯甲酸合成路线 （共 18 条）
反应条件
sodium hypochlorite Oxidation;
参考文献
Braish, Tamim F.; Fox, Darrell E.
Organic Preparations and Procedures International, 1991 , vol. 23, # 5 p. 655 - 658
反应条件
KF; benzenesulfonyl chloride in sulfolane; thionyl chloride
参考文献
Abbott Laboratories
Patent: US5576455 A1, 1996 ;
反应条件
sodium nitrate; copper(l) chloride in hydrogenchloride; water
反应条件
hydrogenchloride in sodium hypobromide
反应条件
hydrogenchloride in water; acetonitrile
反应条件
hydrogenchloride; sodium hydroxide; bromine in sodium hypobromide
反应条件
1: H2 / 5 percent Pt/C / 1,2-dimethoxy-ethane / 24 h / 2585.74 Torr 2: BF3*Et2O; t-BuONO / 1,2-dimethoxy-ethane / 1 h / -5 °C 3: 49 percent / 0.5 h / 170 °C 4: 80 percent / AlCl3 5: 90 percent / 5 percent NaOCl View Scheme
参考文献
Organic Preparations and Procedures International, , vol. 23, # 5 p. 655 - 658
反应条件
1: 52 percent / KF; 18-crown-6 / tetrahydrothiophene 1,1-dioxide / 32 h / 180 °C 2: H2 / 5 percent Pt/C / 1,2-dimethoxy-ethane / 24 h / 2585.74 Torr 3: BF3*Et2O; t-BuONO / 1,2-dimethoxy-ethane / 1 h / -5 °C 4: 49 percent / 0.5 h / 170 °C 5: 80 percent / AlCl3 6: 90 percent / 5 percent NaOCl View Scheme
参考文献
Organic Preparations and Procedures International, , vol. 23, # 5 p. 655 - 658
反应条件
1: BF3*Et2O; t-BuONO / 1,2-dimethoxy-ethane / 1 h / -5 °C 2: 49 percent / 0.5 h / 170 °C 3: 80 percent / AlCl3 4: 90 percent / 5 percent NaOCl View Scheme
参考文献
Organic Preparations and Procedures International, , vol. 23, # 5 p. 655 - 658
