1: With magnesium in tetrahydrofuran 3 h; Heating; 2: With boric acid trimethyl ester in tetrahydrofuran T=-78 - 20°C; 3: With hydrogenchloride in tetrahydrofuran
sulfuric acid; iodine; magnesium in diethyl ether addn. of 1-bromohexane and I2 to Mg turnings suspended in ether, refluxing; slow addn. of n-hexylmagnesium bromide to trimethylborate in ether at -78°C, stirring overnight, cooling to 0°C, addn. of H2SO4, stirring (20 min at room temp.); extn. the aq. phase with ether, washing the organic phase with water andbrine, drying over MgSO4, filtration, concg. in vac.;
Carrigan, Christina N.; Bartlett, Richard D.; Esslinger, C. Sean; Cybulski, Kimberly A.; Tongcharoensirikul, Pakamas; Bridges, Richard J.; Thompson, Charles M.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 11 p. 2260 - 2276
