反应条件
1: 1.) O3, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 2.) RT
2: 1.) tert-BuOK, 3.) LAH / 1.) THF, RT, 30 min, 2.) THF, 1 h, 3.) ether, RT, 4 h
3: 1.) (COCl)2, DMSO, 3.) triethylamine / 1.) CH2Cl2, -70 deg C, 5 min, 2.) 20 min, -70 deg C, 3.) 5 min at -70 deg C, -70 deg C to RT
4: 1.) n-BuLi / 1.) THF, tetramethylethylenediamine, hexane, 0 to 20 deg C; 2.) THF, RT, 1 h
5: Lithium / tetrahydrofuran; liquid ammonia / -30 °C / large excess of lithium
6: 93 percent / 48 percent HBr / ethanol / 0.25 h / 65 °C
7: 81 percent / O2 / salcomine / dimethylformamide / 3 h / Ambient temperature
8: 77 percent / 70 percent HClO4 / CH2Cl2 / 1 h / Ambient temperature
View Scheme
参考文献
Kubo, Isao; Kim, Mujo; Ganjian, Iraj; Kamikawa, Tadao; Yamagiwa, Yoshiro
Tetrahedron, 1987 , vol. 43, # 12 p. 2653 - 2660
