1: 100 percent / camphorsulfonic acid monohydrate / CHCl3 / 22.5 h / Ambient temperature 2: MAP / pyridine; CH2Cl2 / 48 h / Ambient temperature 3: 97 percent / osmium tetroxide, N-methylmorpholine-N-oxide / 2-methyl-propan-2-ol; tetrahydrofuran-d8; H2O / 120 h / Ambient temperature 4: 100 percent / triethylamine, water / methanol / 68 h / Ambient temperature View Scheme

Multi-step reaction with 2 steps 1: 84 percent / DMAP / pyridine / 1.) 0 deg C, 2.5 h, 2.) RT2: 73 percent / m-CPBA / CH2Cl2 / 22 h / Ambient temperature; pH 8 phosphate buffer