1: 92 percent / Na-methylate / methanol / 5 h / Ambient temperature 2: K-tert-butoxide / 1,2-dimethoxy-ethane 4: 33 percent / tetrakis(triphenylphosphine)palladium, n-butylamine, copper iodide / benzene / Ambient temperature 5: 70 percent / Zn dust / methanol; H2O / Ambient temperature 6: 95 percent / K2CO3 / methanol; H2O / 18 h / Ambient temperature View Scheme

Multi-step reaction with 2 steps 1: MeONa / methanol / Ambient temperature2: t-BuOK / 1,2-dimethoxy-ethane / from -78 deg C to room temperature