1-苄基-3-[(三甲基硅烷基)氧基]吖丁啶合成路线 （共 11 条）
反应条件
triethylamine in acetonitrile 72 h; Heating / reflux;
参考文献
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Patent: WO2006/25634 A1, 2006 ;
Location in patent: Page/Page column 15-16 ;
反应条件
1: 89 percent / Et3N / CH2Cl2 / 3 h / 20 °C 2: 71 percent / Et3N / acetonitrile / 48 h / Heating View Scheme
参考文献
Higgins, Robert H.; Eaton, Quentin L.; Worth, Leroy; Peterson, Myra V.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 255 - 259
反应条件
1: 96 percent / hexane / 15 h / 20 °C 2: 89 percent / Et3N / CH2Cl2 / 3 h / 20 °C 3: 71 percent / Et3N / acetonitrile / 48 h / Heating View Scheme
参考文献
Higgins, Robert H.; Watson, Monique R.; Faircloth, William J.; Eaton, Quentin L.; Jenkins, Harvey
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 383 - 387
反应条件
triethylamine in acetonitrile Heating;
参考文献
Higgins, Robert H.; Eaton, Quentin L.; Worth, Leroy; Peterson, Myra V.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 255 - 259
反应条件
1H-imidazole; acetonitrile; trimethylamine 1) 1.5 h, 2) reflux 3 days; Yield given. Multistep reaction;
参考文献
Higgins, Robert H.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1489 - 1491
反应条件
triethylamine; acetonitrile 72 h; Heating; Yield given;
参考文献
Higgins, Robert H.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1489 - 1491
反应条件
triethylamine acetonitrile, reflux, 3 days; Yield given. Multistep reaction;
参考文献
Higgins, Robert H.; Watson, Monique R.; Faircloth, William J.; Eaton, Quentin L.; Jenkins, Harvey
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 383 - 387
反应条件
hydrogen; 10 palladium hydroxide on carbon powder in methanol 7 - 18 h; Product distribution / selectivity;
参考文献
PHARMACIA and UPJOHN COMPANY LLC
Patent: WO2007/4049 A1, 2007 ;
Location in patent: Page/Page column 16-17; 41-42 ;
反应条件
hydrogenchloride; sodium hydroxide in water 0.0833333 h; Ambient temperature;
参考文献
Higgins, Robert H.; Eaton, Quentin L.; Worth, Leroy; Peterson, Myra V.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 255 - 259
反应条件
1: 77 percent / CH3ONa / methanol / 1 h / Ambient temperature 2: 1.06 g / Py*SO3, Et3N / dimethylsulfoxide / 0.5 h / 40 °C View Scheme
参考文献
Katritzky, Alan R.; Cundy, Darren J.; Chen, Jie
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 2 p. 271 - 276
