2-(三甲基甲硅烷基)呋喃并[3,2-b]吡啶合成路线 (共 4 条)
反应条件
1: With copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride in 1,4-dioxane 0.0833333 h; Inert atmosphere; 2: With triethylamine in 1,4-dioxane T=500°C; 18 h;
参考文献
MERCK PATENT GMBH; BURGDORF, Lars; ROSS, Tatjana; DEUTSCH, Carl
Patent: WO2013/124025 A1, 2013 ;
Location in patent: Page/Page column 71; 72 ;
反应条件
1: furolt;3,2-bgt;pyridine With n-butyllithium in tetrahydrofuran T=-78°C; 1 h; 2: chloro-trimethyl-silane in tetrahydrofuran T=-78°C; 1 h; Further stages.;
参考文献
Chartoire, Anthony; Comoy, Corinne; Fort, Yves
Tetrahedron, 2008 , vol. 64, # 48 p. 10867 - 10873
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine T=120°C; 24 h;
参考文献
Sakamoto, Takao; Kondo, Yoshinori; Watanabe, Ryo; Yamanaka, Hiroshi
Chemical & Pharmaceutical Bulletin, 1986 , vol. 34, # 7 p. 2719 - 2724
反应条件
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C 2: trichlorophosphate / 2 h / 100 °C / Sealed tube 3: potassium fluoride; N-iodo-succinimide / acetonitrile / 2 h / 20 - 50 °C / Inert atmosphere View Scheme
参考文献
MERCK PATENT GMBH; BURGDORF, Lars; ROSS, Tatjana; DEUTSCH, Carl
Patent: WO2013/124025 A1, 2013 ;