7-(三氟甲基)色满-4-酮合成路线 （共 12 条）
反应条件
1: With manganese bromide tetrahydrate; potassium hexamethylsilazane in tetrahydrofuran; toluene
T=-78°C; 0.5 h;
2: With N-fluoro-N-(phenylsulfonyl)benzene-sulfonamide in tetrahydrofuran; toluene
T=-78 - 0°C; 4 h;
参考文献
MOCHIDA PHARMACEUTICAL CO., LTD.
Patent: EP1908753 A1, 2008 ;
Location in patent: Page/Page column 104-105 ;
反应条件
1: pyridine / 24 h / 20 °C
2: palladium 10 on activated carbon; ammonia; hydrogen / methanol / 1 h / 20 °C / 3102.97 Torr
View Scheme
参考文献
Schmidt, Robert G.; Bayburt, Erol K.; Latshaw, Steven P.; Koenig, John R.; Daanen, Jerome F.; McDonald, Heath A.; Bianchi, Bruce R.; Zhong, Chengmin; Joshi, Shailen; Honore, Prisca; Marsh, Kennan C.; Lee, Chih-Hung; Faltynek, Connie R.; Gomtsyan, Arthur
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1338 - 1341
