[4-(4-氨基-6-溴喹唑啉-2-基)哌嗪-1-基]-呋喃-2-基甲酮盐酸盐合成路线 （共 4 条）
反应条件
in N,N-dimethyl-formamide
T=95°C; 14 h;
参考文献
Volzhina, O. N.; Azimov, V. A.; Medvedev, B. A.; Kazakov, A. A.; Zhikhareva, G. P.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 7 p. 478 - 483
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 7 p. 802 - 807
反应条件
1: 95.2 percent / POCl3, N,N-dimethylaniline / Heating
2: 74 percent / NH3(g) / dimethylformamide / 0.67 h / 35 - 40 °C
3: 96.4 percent / dimethylformamide / 14 h / 95 °C
View Scheme
参考文献
Volzhina, O. N.; Azimov, V. A.; Medvedev, B. A.; Kazakov, A. A.; Zhikhareva, G. P.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 7 p. 478 - 483
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 7 p. 802 - 807
反应条件
1: 74 percent / NH3(g) / dimethylformamide / 0.67 h / 35 - 40 °C
2: 96.4 percent / dimethylformamide / 14 h / 95 °C
View Scheme
参考文献
Volzhina, O. N.; Azimov, V. A.; Medvedev, B. A.; Kazakov, A. A.; Zhikhareva, G. P.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 7 p. 478 - 483
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 7 p. 802 - 807
反应条件
1: 78.5 percent / 2 h / 180 - 210 °C
2: 95.2 percent / POCl3, N,N-dimethylaniline / Heating
3: 74 percent / NH3(g) / dimethylformamide / 0.67 h / 35 - 40 °C
4: 96.4 percent / dimethylformamide / 14 h / 95 °C
View Scheme
参考文献
Volzhina, O. N.; Azimov, V. A.; Medvedev, B. A.; Kazakov, A. A.; Zhikhareva, G. P.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 7 p. 478 - 483
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 7 p. 802 - 807
