[4-(4-氨基-7-氯-6,8-二硝基喹唑啉-2-基)哌嗪-1-基]-呋喃-2-基甲酮盐酸盐合成路线 （共 5 条）
反应条件
in butan-1-ol T=95°C; 14 h;
参考文献
Volzhina, O. N.; Azimov, V. A.; Medvedev, B. A.; Kazakov, A. A.; Zhikhareva, G. P.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 7 p. 478 - 483
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 7 p. 802 - 807
反应条件
1: 90.4 percent / fuming nitric acid, conc. sulfuric acid / 4 h / 60 - 80 °C 2: 97 percent / POCl3, N,N-dimethylaniline / Heating 3: 82 percent / NH3(g) / dimethylformamide / 0.67 h / 35 - 40 °C 4: 59.7 percent / butan-1-ol / 14 h / 95 °C View Scheme
参考文献
Volzhina, O. N.; Azimov, V. A.; Medvedev, B. A.; Kazakov, A. A.; Zhikhareva, G. P.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 7 p. 478 - 483
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 7 p. 802 - 807
反应条件
1: 82 percent / NH3(g) / dimethylformamide / 0.67 h / 35 - 40 °C 2: 59.7 percent / butan-1-ol / 14 h / 95 °C View Scheme
参考文献
Volzhina, O. N.; Azimov, V. A.; Medvedev, B. A.; Kazakov, A. A.; Zhikhareva, G. P.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 7 p. 478 - 483
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 7 p. 802 - 807
反应条件
1: 97 percent / POCl3, N,N-dimethylaniline / Heating 2: 82 percent / NH3(g) / dimethylformamide / 0.67 h / 35 - 40 °C 3: 59.7 percent / butan-1-ol / 14 h / 95 °C View Scheme
参考文献
Volzhina, O. N.; Azimov, V. A.; Medvedev, B. A.; Kazakov, A. A.; Zhikhareva, G. P.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 7 p. 478 - 483
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 7 p. 802 - 807
反应条件
1: 2 h / 180 - 210 °C 2: 90.4 percent / fuming nitric acid, conc. sulfuric acid / 4 h / 60 - 80 °C 3: 97 percent / POCl3, N,N-dimethylaniline / Heating 4: 82 percent / NH3(g) / dimethylformamide / 0.67 h / 35 - 40 °C 5: 59.7 percent / butan-1-ol / 14 h / 95 °C View Scheme
参考文献
Volzhina, O. N.; Azimov, V. A.; Medvedev, B. A.; Kazakov, A. A.; Zhikhareva, G. P.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 7 p. 478 - 483
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 7 p. 802 - 807
