6-溴-2-氯喹唑啉-4-胺合成路线 （共 4 条）
反应条件
ammonia in N,N-dimethyl-formamide T=35 - 40°C; 0.666667 h;
参考文献
Pharmaceutical Chemistry Journal, , vol. 21, # 7 p. 478 - 483
Khimiko-Farmatsevticheskii Zhurnal, , vol. 21, # 7 p. 802 - 807
反应条件
1: 95.2 percent / POCl3, N,N-dimethylaniline / Heating 2: 74 percent / NH3(g) / dimethylformamide / 0.67 h / 35 - 40 °C View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 21, # 7 p. 478 - 483
Khimiko-Farmatsevticheskii Zhurnal, , vol. 21, # 7 p. 802 - 807
反应条件
1: 78.5 percent / 2 h / 180 - 210 °C 2: 95.2 percent / POCl3, N,N-dimethylaniline / Heating 3: 74 percent / NH3(g) / dimethylformamide / 0.67 h / 35 - 40 °C View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 21, # 7 p. 478 - 483
Khimiko-Farmatsevticheskii Zhurnal, , vol. 21, # 7 p. 802 - 807
反应条件
in N,N-dimethyl-formamide
T=95°C; 14 h;
参考文献
Volzhina, O. N.; Azimov, V. A.; Medvedev, B. A.; Kazakov, A. A.; Zhikhareva, G. P.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 7 p. 478 - 483
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 7 p. 802 - 807
