chlorine in hexane; di-isopropyl ether; water

sodium hydroxide; chloro-trimethyl-silane; sulfuryl dichloride; triethylamine in tetrahydrofuran; anhydrous xylene; nitrogen; water; acetonitrile

1: 4-chloro-2-methoxyimino-3-oxo-butyric acid With phosphorus pentachloride in dichloromethane T=-20 - 0°C; 2: C16H20N2O5S2Si in dichloromethane T=-50 - 0°C; 3: thiourea With sodium hydrogencarbonate; trifluoroacetic acid; sodium 2-ethyl hexanoate Product distribution / selectivity; more than 3 stages;

1: 4-chloro-2-methoxyimino-3-oxo-butyric acid With phosphorus pentachloride in dichloromethane T=-20 - 0°C; 2: (6R,7R)-7-amino-3-(furan-2-carbonylsulfanylmethyl)cephalosporanic acid With ammonia in tetrahydrofuran; dichloromethane; water pH=5.5 - 8.5; 3: thiourea With sodium hydrogencarbonate; trifluoroacetic acid; sodium 2-ethyl hexanoate Product distribution / selectivity; more than 3 stages;

1: 4-chloro-2-methoxyimino-3-oxo-butyric acid With phosphorus pentachloride in dichloromethane T=-5 - 0°C; 1 h; 2: (7R)-7-aminocephalosporanic acid With ammonia in water; acetone T=-5 - 0°C; pH=6.5 - 7; 0.5 - 0.666667 h; 3: thiourea With sodium acetate in water; acetone T=18 - 20°C; 1 h;