4-甲氧吲哚-2-羧酸甲脂合成路线 （共 24 条）
反应条件
Rh2(pbf)4 in toluene T=60°C; 16 h;
参考文献
Stokes, Benjamin J.; Dong, Huijun; Leslie, Brooke E.; Pumphrey, Ashley L.; Driver, Tom G.
Journal of the American Chemical Society, 2007 , vol. 129, # 24 p. 7500 - 7501
反应条件
1: 38 percent / sodium methoxide / methanol / 4 h / -10 °C 2: 91 percent / Rh2(pbf)4 / toluene / 16 h / 60 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 129, # 24 p. 7500 - 7501
反应条件
1: FeSO4/NH3 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 5 p. 944 - 948
反应条件
1: With tetrabutyl-ammonium chloride; sodium formate; sodium hydrogencarbonate; palladium diacetate; sodium chloride Heck coupling; 1 h; 2: With acetic anhydride 12 h; Heating;
参考文献
Tullberg, Erik; Schacher, Felix; Peters, Dan; Frejd, Torbjoern
Synthesis, 2006 , # 7 p. 1183 - 1189
反应条件
1.1: 97 percent / K2CO3 / dimethylformamide / 20 °C 2.1: 60 percent / Fe; AcOH / ethanol / 3.5 h / Heating 3.1: NaHCO3; HCO2Na; n-Bu4NCl / Pd(OAc)2; NaCl / 1 h 3.2: 58 percent / Ac2O / 12 h / Heating View Scheme
参考文献
Synthesis, , # 7 p. 1183 - 1189
反应条件
1.1: 60 percent / Fe; AcOH / ethanol / 3.5 h / Heating 2.1: NaHCO3; HCO2Na; n-Bu4NCl / Pd(OAc)2; NaCl / 1 h 2.2: 58 percent / Ac2O / 12 h / Heating View Scheme
参考文献
Synthesis, , # 7 p. 1183 - 1189
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate
参考文献
Australian Journal of Chemistry, , vol. 40, # 9 p. 1527 - 1536
反应条件
1: EtOK / ethanol / Heating 2: aq. HCl 3: FeSO4/NH3 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 5 p. 944 - 948
反应条件
hydrogen; acetic acid; zinc; palladium on activated charcoal 1.) ethyl acetate, 2.) water, reflux; Yield given. Multistep reaction;
参考文献
Australian Journal of Chemistry, , vol. 40, # 9 p. 1527 - 1536
反应条件
1: aq. HCl 2: FeSO4/NH3 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 5 p. 944 - 948
