4-甲氧吲哚-2-羧酸甲脂合成路线 （共 24 条）
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 5 p. 944 - 948
反应条件
NaH; ammonium chloride in N,N-dimethyl-formamide; mineral oil
参考文献
Affinium Pharmaceuticals, Inc.
Patent: EP1226138 B1, 2004 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide 18 h;
参考文献
Arbain, Dayar; Sargent, Melvyn V.
Australian Journal of Chemistry, 1987 , vol. 40, # 9 p. 1527 - 1536
反应条件
1: 99 percent / aq. NaOH / 0.5 h / Heating 2: 94 percent / Cu; quinoline / 2 h / Heating View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1: 99 percent / aq. NaOH / 0.5 h / Heating 2: 94 percent / Cu; quinoline / 2 h / Heating 3: 85 percent / phosphoryl chloride / 1.5 h / 0 - 40 °C View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1: With boron tribromide in dichloromethane T=0°C; 2 h; 2: With water; sodium hydrogencarbonate in dichloromethane pH=7;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GmbH
Patent: WO2005/77932 A2, 2005 ;
Location in patent: Page/Page column 60 ;
WO 2005/077932 A2
反应条件
sodium hydroxide 0.5 h; Heating;
参考文献
Meiji Dairies Corporation
Patent: EP1533299 A1, 2005 ;
Location in patent: Page/Page column 8 ;
反应条件
1.1: 99 percent / aq. NaOH / 0.5 h / Heating
2.1: 94 percent / Cu; quinoline / 2 h / Heating
3.1: 85 percent / phosphoryl chloride / 1.5 h / 0 - 40 °C
4.1: NaOH / CH2Cl2 / 0.5 h / 20 °C
4.2: 97 percent / CH2Cl2 / 12 h / 20 °C
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: 99 percent / aq. NaOH / 0.5 h / Heating
2.1: 94 percent / Cu; quinoline / 2 h / Heating
3.1: 85 percent / phosphoryl chloride / 1.5 h / 0 - 40 °C
4.1: NaOH / CH2Cl2 / 0.5 h / 20 °C
4.2: 97 percent / CH2Cl2 / 12 h / 20 °C
5.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / 0 °C
5.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0.25 h / 0 °C
5.3: 74 percent / tetrahydrofuran; hexane / 2.5 h / -78 - 0 °C
6.1: 93 percent / H2 / Pd/C / ethanol / 4 h / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: 99 percent / aq. NaOH / 0.5 h / Heating
2.1: 94 percent / Cu; quinoline / 2 h / Heating
3.1: 85 percent / phosphoryl chloride / 1.5 h / 0 - 40 °C
4.1: NaOH / CH2Cl2 / 0.5 h / 20 °C
4.2: 97 percent / CH2Cl2 / 12 h / 20 °C
5.1: n-BuLi; potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C
5.2: 71 percent / tetrahydrofuran; hexane / -78 - 0 °C
6.1: 94 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
