4-甲氧基-1-甲基-1H-吲哚-2-羧酸甲酯合成路线 （共 7 条）
反应条件
NaH; ammonium chloride in N,N-dimethyl-formamide; mineral oil
参考文献
Affinium Pharmaceuticals, Inc.
Patent: EP1226138 B1, 2004 ;
反应条件
1: FeSO4/NH3 3: NaH / dimethylsulfoxide View Scheme
参考文献
Arbain, Dayar; Sargent, Melvyn V.
Australian Journal of Chemistry, 1987 , vol. 40, # 9 p. 1527 - 1536
反应条件
1: 1.) hydrogen, 2.) zinc, acetic acid / 1.) palladized charcoal / 1.) ethyl acetate, 2.) water, reflux 2: 11.9 g / potassium carbonate / dimethylformamide / 18 h View Scheme
参考文献
Arbain, Dayar; Sargent, Melvyn V.
Australian Journal of Chemistry, 1987 , vol. 40, # 9 p. 1527 - 1536
反应条件
potassium carbonate in N,N-dimethyl-formamide 18 h;
参考文献
Arbain, Dayar; Sargent, Melvyn V.
Australian Journal of Chemistry, 1987 , vol. 40, # 9 p. 1527 - 1536
反应条件
2: NaH / dimethylsulfoxide View Scheme
参考文献
Fagan, Gay P.; Chapleo, Christopher B.; Lane, Anthony C.; Myers, Malcolm; Roach, Alan G.; et al
Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 944 - 948
反应条件
1: EtOK / ethanol / Heating 2: aq. HCl 3: FeSO4/NH3 5: NaH / dimethylsulfoxide View Scheme
参考文献
Fagan, Gay P.; Chapleo, Christopher B.; Lane, Anthony C.; Myers, Malcolm; Roach, Alan G.; et al
Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 944 - 948
反应条件
1: aq. HCl 2: FeSO4/NH3 4: NaH / dimethylsulfoxide View Scheme
参考文献
Fagan, Gay P.; Chapleo, Christopher B.; Lane, Anthony C.; Myers, Malcolm; Roach, Alan G.; et al
Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 944 - 948
