N-(5-溴噻唑并[5,4-b]吡啶-2-基)乙酰胺合成路线 (共 4 条)
反应条件
in acetone T=65 - 70°C; 2.5 h;
参考文献
AMGEN INC.
Patent: WO2009/17822 A2, 2009 ;
Location in patent: Page/Page column 81 ;
WO 2009/017822 A2
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; DONG, Qing; GONG, Xianchang; HIROSE, Masaaki; JIN, Bohan; ZHOU, Feng
Patent: WO2010/8847 A2, 2010 ;
Location in patent: Page/Page column 123 ;
反应条件
in isopropyl alcohol T=80°C; 16 h;
参考文献
WO2009/129211 A1, ;
Page/Page column 34-35; 37 ;
WO 2009/129211 A1
反应条件
1: With hydrogenchloride; water 1 h; Reflux; 2: in water T=20°C; pH=10;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2009/129211 A1, 2009 ;
Location in patent: Page/Page column 35; 37 ;
WO 2009/129211 A1