反应条件
1: H2O 2: aq. NaOH / tetrahydrofuran 3: 1.) Et3N, DPP-Cl, 2.) Et3N / 1.) EtOAc, 0 deg C, 1 h, 2.) EtOAc, overnight 4: 4 N HCl / dioxane / 2 h 5: HOBt, EDC*HCl / dimethylformamide 6: 4 N HCl / CH2Cl2; dioxane / 3 h 7: 1.) Et3N, DPP-Cl, 2.) Et3N / 1.) EtOAc, 0 deg C, 1 h, 2.) EtOAc, overnight 8: 1 N NaOH / methanol / 1 h View Scheme
参考文献
Mimoto, Tsutomu; Kato, Ryohei; Takaku, Haruo; Nojima, Satoshi; Terashima, Keisuke; Misawa, Satoru; Fukazawa, Tominaga; Ueno, Takamasa; Sato, Hideharu; Shintani, Makoto; Kiso, Yoshiaki; Hayashi, Hideya
Journal of Medicinal Chemistry, 1999 , vol. 42, # 10 p. 1789 - 1802
