反应条件
1: H2O
2: aq. NaOH / tetrahydrofuran
3: DCC / tetrahydrofuran / 1 h / 0 °C
4: tetrahydrofuran
5: 4 N HCl / dioxane / 2 h
6: HOBt, DCC / dimethylformamide
7: 4 N HCl / CH2Cl2; dioxane / 2 h
8: 92 percent / HOBt*H2O, EDC*HCl / dimethylformamide
View Scheme
参考文献
Mimoto, Tsutomu; Kato, Ryohei; Takaku, Haruo; Nojima, Satoshi; Terashima, Keisuke; Misawa, Satoru; Fukazawa, Tominaga; Ueno, Takamasa; Sato, Hideharu; Shintani, Makoto; Kiso, Yoshiaki; Hayashi, Hideya
Journal of Medicinal Chemistry, 1999 , vol. 42, # 10 p. 1789 - 1802
