6-氯-5-(三氟甲基)烟醛合成路线 （共 4 条）
反应条件
1: 2-chloro-5-iodo-3-trifluoromethylpyridine With n-butyllithium in tetrahydrofuran; hexane; toluene T=-78°C; 1.66667 h; 2: formic acid ethyl ester in tetrahydrofuran; hexane; toluene 1.66667 h;
参考文献
WO2009/18657 A1, ;
Page/Page column 71 ;
反应条件
1: in tetrahydrofuran; hexane; toluene T=-78°C; 1.66667 h; 2: With hydrogenchloride in tetrahydrofuran; hexane; water; toluene T=-78°C; Acidic aqueous solution;
参考文献
WO2009/18656 A1, ;
Page/Page column 54-55 ;
反应条件
1: With sodium tetrahydroborate in methanol T=0°C; 2 h; 2: With sodium hydrogen sulphate in methanol; water T=0°C; Acidic aqueous solution;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GmbH
Patent: WO2009/76747 A1, 2009 ;
Location in patent: Page/Page column 62-63 ;
反应条件
1: With sodium tetrahydroborate in methanol
T=0°C; 2 h;
2: With sodium hydrogen sulphate in methanol; water
T=0°C; Acidic aqueous solution;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GmbH
Patent: WO2009/18656 A1, 2009 ;
Location in patent: Page/Page column 67 ;
