3-(3-氧代丙基)苯甲酸甲酯合成路线 （共 4 条）
反应条件
in toluene
T=200°C; 16 h; Inert atmosphere;
参考文献
Lee, Jennifer J.; Kraus, George A.
Tetrahedron Letters, 2013 , vol. 54, # 19 p. 2366 - 2368
反应条件
N,N-dicyclohexylmethylamine; potassium carbonate; bis(dibenzylideneacetone)-palladium(0); cataCXium PIntB in N,N-dimethyl-formamide
T=100°C; 0.5 h; Molecular sieveInert atmosphere;
参考文献
Colbon, Paul; Ruan, Jiwu; Purdie, Mark; Mulholland, Keith; Xiao, Jianliang
Organic Letters, 2011 , vol. 13, # 20 p. 5456 - 5459
反应条件
1.1: PdCl2(dppf) / diethyl ether / 24 h / 20 °C
2.1: 1.33 g / p-TsOH / acetone / 4 h / 20 °C
3.1: 93 percent / NaCN; MnO2; HOAc / 12 h / 20 °C
4.1: O3 / CH2Cl2 / -78 °C
4.2: 82 percent / Me2S / CH2Cl2 / 20 °C
View Scheme
参考文献
Kuo, Chih-Wei; Fang, Jim-Min
Synthetic Communications, 2001 , vol. 31, # 6 p. 877 - 892
反应条件
1: NaBH4 / H2O; tetrahydrofuran / 2 h / Ambient temperature
2: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -40 deg C, 25 min, 2.) CH2Cl2, -40 deg C, 5 min
View Scheme
参考文献
Hashizume; Ito; Yamada; Nagashima; Kanao; Tomoda; Sunazuka; Kumagai; Omura
Chemical and pharmaceutical bulletin, 1994 , vol. 42, # 3 p. 512 - 520
