(S)-(-)-1,1,1-三氟-2-癸醇合成路线 （共 13 条）
反应条件
hydrogen; platinum(IV) oxide; lipase-MY (Candida cylindracea)
1.) H2O; 2.) EtOH; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Kitazume, Tomoya; Lin, Jeng Tain; Yamazaki, Takashi; Takeda, Mitsunori
Journal of Fluorine Chemistry, 1989 , vol. 43, p. 177 - 188
反应条件
in diethyl ether
24 h; Ambient temperature; Title compound not separated from byproducts;
参考文献
Lin, Jenq Tain; Yamazaki, Takashi; Kitazume, Tomoya
Journal of Organic Chemistry, 1987 , vol. 52, # 15 p. 3211 - 3217
反应条件
1: 1.) LDA / 1.) THF, -78 deg C, 30 min., 2.) THF, r.t., 24 h
2: (-)-B-chlorodiisopinocampheylborane / 7.5 h / Ambient temperature
View Scheme
参考文献
Ramachandran, P. Veeraraghavan; Teodorovic, Aleksandar V.; Brown, Herbert C.
Tetrahedron, 1993 , vol. 49, # 9 p. 1725 - 1738
