potassium hydroxide in ethanol T=23°C; 4 h;

With  n-butyllithium; diisopropylamine in  tetrahydrofuran; hexane; water; ethyl acetate Show Experimental Procedure  

Multi-step reaction with 6 steps 1: CH3SO3H / 3 h / 23 °C2: Ac2O, TEA / dimethylformamide / 1 h3: HCl / H2O4: Pb(OAc)4 / CH2Cl2 / 3 h / Heating5: 12.9 g / 3N HCl / acetone; H2O / 1 h / Heating6: 1.) LDA / 1.) THF, hexane, -78 deg C, 2.) THF, hexane, -78 to -65 deg C  

Multi-step reaction with 8 steps 1: 252.2 g / NaBH4, H2O / tetrahydrofuran / 20 h / 23 °C2: triphenylphosphine, Br2 / toluene / 20 h / 23 °C3: CH3SO3H / 3 h / 23 °C4: Ac2O, TEA / dimethylformamide / 1 h5: HCl / H2O6: Pb(OAc)4 / CH2Cl2 / 3 h / Heating7: 12.9 g / 3N HCl / acetone; H2O / 1 h / Heating8: 1.) LDA / 1.) THF, hexane, -78 deg C, 2.) THF, hexane, -78 to -65 deg C  

Multi-step reaction with 5 steps 1: Ac2O, TEA / dimethylformamide / 1 h2: HCl / H2O3: Pb(OAc)4 / CH2Cl2 / 3 h / Heating4: 12.9 g / 3N HCl / acetone; H2O / 1 h / Heating5: 1.) LDA / 1.) THF, hexane, -78 deg C, 2.) THF, hexane, -78 to -65 deg C