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结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
111478-81-0
合成路线
（共 8 条）
111478-81-0
→
反应条件
111478-86-5
(1,8-二乙基-4-氧代-1,3,4,9-四氢吡喃并[3,4-b]吲哚-1-基)乙酸
反应条件
1: 80.5 percent / paraformaldehyde / H2O / 1 h / Heating 2: 64 percent / manganese dioxide / H2O / 18 h / Ambient temperature 3: 93 percent / K2CO3 / methanol; H2O / 2 h / Heating View Scheme
参考文献
Humber; Ferdinandi; Demerson; Ahmed; Shah; Mobilio; Sabatucci; De Lange; Labbadia; Hughes; DeVirgilio; Neuman; Chau; Weichman
Journal of Medicinal Chemistry, 1988 , vol. 31, # 9 p. 1712 - 1719
111478-81-0
→
反应条件
111478-84-3
甲基(1,8-二乙基-4-氧代-1,3,4,9-四氢吡喃并[3,4-b]吲哚-1-基)乙酸酯
反应条件
1: 80.5 percent / paraformaldehyde / H2O / 1 h / Heating 2: 64 percent / manganese dioxide / H2O / 18 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 9 p. 1712 - 1719
111478-92-3
→
反应条件
111478-81-0
反应条件
Multi-step reaction with 6 steps 1: 87 percent / hydrogen, conc. HCl / 10percent Pd/C / ethanol / 4 h / 22 °C2: 85.7 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating3: 98 percent / H2O / 16 h4: 90 percent / 5percent aq. K2CO3 / methanol / 2 h / 55 °C5: 62.3 percent / boron trifluoride etherate / CH2Cl2 / 24 h / 22 °C6: 50 percent / 1 N methanolic HCl / 72 h / 25 °C
参考文献
Humber; Ferdinandi; Demerson; Ahmed; Shah; Mobilio; Sabatucci; De Lange; Labbadia; Hughes; DeVirgilio; Neuman; Chau; Weichman Journal of Medicinal Chemistry, 1988 , vol. 31, # 9 p. 1712 - 1719
111478-94-5
→
反应条件
111478-81-0
反应条件
Multi-step reaction with 4 steps 1: 98 percent / H2O / 16 h2: 90 percent / 5percent aq. K2CO3 / methanol / 2 h / 55 °C3: 62.3 percent / boron trifluoride etherate / CH2Cl2 / 24 h / 22 °C4: 50 percent / 1 N methanolic HCl / 72 h / 25 °C
参考文献
Humber; Ferdinandi; Demerson; Ahmed; Shah; Mobilio; Sabatucci; De Lange; Labbadia; Hughes; DeVirgilio; Neuman; Chau; Weichman Journal of Medicinal Chemistry, 1988 , vol. 31, # 9 p. 1712 - 1719
111478-96-7
→
反应条件
111478-81-0
反应条件
Multi-step reaction with 2 steps 1: 62.3 percent / boron trifluoride etherate / CH2Cl2 / 24 h / 22 °C2: 50 percent / 1 N methanolic HCl / 72 h / 25 °C
参考文献
Humber; Ferdinandi; Demerson; Ahmed; Shah; Mobilio; Sabatucci; De Lange; Labbadia; Hughes; DeVirgilio; Neuman; Chau; Weichman Journal of Medicinal Chemistry, 1988 , vol. 31, # 9 p. 1712 - 1719
111478-93-4
→
反应条件
111478-81-0
反应条件
Multi-step reaction with 5 steps 1: 85.7 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating2: 98 percent / H2O / 16 h3: 90 percent / 5percent aq. K2CO3 / methanol / 2 h / 55 °C4: 62.3 percent / boron trifluoride etherate / CH2Cl2 / 24 h / 22 °C5: 50 percent / 1 N methanolic HCl / 72 h / 25 °C
参考文献
Humber; Ferdinandi; Demerson; Ahmed; Shah; Mobilio; Sabatucci; De Lange; Labbadia; Hughes; DeVirgilio; Neuman; Chau; Weichman Journal of Medicinal Chemistry, 1988 , vol. 31, # 9 p. 1712 - 1719
111478-95-6
→
反应条件
111478-81-0
反应条件
Multi-step reaction with 3 steps 1: 90 percent / 5percent aq. K2CO3 / methanol / 2 h / 55 °C2: 62.3 percent / boron trifluoride etherate / CH2Cl2 / 24 h / 22 °C3: 50 percent / 1 N methanolic HCl / 72 h / 25 °C
参考文献
Humber; Ferdinandi; Demerson; Ahmed; Shah; Mobilio; Sabatucci; De Lange; Labbadia; Hughes; DeVirgilio; Neuman; Chau; Weichman Journal of Medicinal Chemistry, 1988 , vol. 31, # 9 p. 1712 - 1719
111478-81-0
→
反应条件
111479-01-7
反应条件
With formaldehyd in water 1 h; Heating;
参考文献
Humber; Ferdinandi; Demerson; Ahmed; Shah; Mobilio; Sabatucci; De Lange; Labbadia; Hughes; DeVirgilio; Neuman; Chau; Weichman Journal of Medicinal Chemistry, 1988 , vol. 31, # 9 p. 1712 - 1719
