1: 85.7 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating 2: 98 percent / H2O / 16 h 3: 90 percent / 5percent aq. K2CO3 / methanol / 2 h / 55 °C 4: 62.3 percent / boron trifluoride etherate / CH2Cl2 / 24 h / 22 °C 5: 50 percent / 1 N methanolic HCl / 72 h / 25 °C 6: 80.5 percent / paraformaldehyde / H2O / 1 h / Heating 7: 64 percent / manganese dioxide / H2O / 18 h / Ambient temperature 8: 93 percent / K2CO3 / methanol; H2O / 2 h / Heating View Scheme

1: 85.7 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating 2: 98 percent / H2O / 16 h 3: 90 percent / 5percent aq. K2CO3 / methanol / 2 h / 55 °C 4: 62.3 percent / boron trifluoride etherate / CH2Cl2 / 24 h / 22 °C 5: 50 percent / 1 N methanolic HCl / 72 h / 25 °C 6: 80.5 percent / paraformaldehyde / H2O / 1 h / Heating 7: 64 percent / manganese dioxide / H2O / 18 h / Ambient temperature View Scheme

Multi-step reaction with 5 steps 1: 85.7 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating2: 98 percent / H2O / 16 h3: 90 percent / 5percent aq. K2CO3 / methanol / 2 h / 55 °C4: 62.3 percent / boron trifluoride etherate / CH2Cl2 / 24 h / 22 °C5: 50 percent / 1 N methanolic HCl / 72 h / 25 °C  

With  hydrogenchloride; hydrogen; palladium on activated charcoal in  ethanol T=22°C; 4 h;   

With  lithium aluminium tetrahydride in  tetrahydrofuran 2 h;  Heating;   

Multi-step reaction with 2 steps 1: 85.7 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating2: 98 percent / H2O / 16 h  

Multi-step reaction with 3 steps 1: 85.7 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating2: 98 percent / H2O / 16 h3: 90 percent / 5percent aq. K2CO3 / methanol / 2 h / 55 °C  

Multi-step reaction with 6 steps 1: 85.7 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating2: 98 percent / H2O / 16 h3: 90 percent / 5percent aq. K2CO3 / methanol / 2 h / 55 °C4: 62.3 percent / boron trifluoride etherate / CH2Cl2 / 24 h / 22 °C5: 50 percent / 1 N methanolic HCl / 72 h / 25 °C6: 80.5 percent / paraformaldehyde / H2O / 1 h / Heating