1: 90 percent / 5percent aq. K2CO3 / methanol / 2 h / 55 °C 2: 62.3 percent / boron trifluoride etherate / CH2Cl2 / 24 h / 22 °C 3: 50 percent / 1 N methanolic HCl / 72 h / 25 °C 4: 80.5 percent / paraformaldehyde / H2O / 1 h / Heating 5: 64 percent / manganese dioxide / H2O / 18 h / Ambient temperature 6: 93 percent / K2CO3 / methanol; H2O / 2 h / Heating View Scheme

1: 90 percent / 5percent aq. K2CO3 / methanol / 2 h / 55 °C 2: 62.3 percent / boron trifluoride etherate / CH2Cl2 / 24 h / 22 °C 3: 50 percent / 1 N methanolic HCl / 72 h / 25 °C 4: 80.5 percent / paraformaldehyde / H2O / 1 h / Heating 5: 64 percent / manganese dioxide / H2O / 18 h / Ambient temperature View Scheme

Multi-step reaction with 3 steps 1: 90 percent / 5percent aq. K2CO3 / methanol / 2 h / 55 °C2: 62.3 percent / boron trifluoride etherate / CH2Cl2 / 24 h / 22 °C3: 50 percent / 1 N methanolic HCl / 72 h / 25 °C  

Multi-step reaction with 3 steps 1: 87 percent / hydrogen, conc. HCl / 10percent Pd/C / ethanol / 4 h / 22 °C2: 85.7 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating3: 98 percent / H2O / 16 h  

Multi-step reaction with 2 steps 1: 85.7 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating2: 98 percent / H2O / 16 h  

With  potassium carbonate in  methanol T=55°C; 2 h;   

Multi-step reaction with 4 steps 1: 90 percent / 5percent aq. K2CO3 / methanol / 2 h / 55 °C2: 62.3 percent / boron trifluoride etherate / CH2Cl2 / 24 h / 22 °C3: 50 percent / 1 N methanolic HCl / 72 h / 25 °C4: 80.5 percent / paraformaldehyde / H2O / 1 h / Heating