1-甲基-3-三氟甲基-1H-吡唑-4-羧酸乙酯合成路线 （共 16 条）
反应条件
1: ethyl 3-(trifluoromethyl)-1H-pyrazole-4-carboxylate With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.333333 h; 2: methyl iodide in N,N-dimethyl-formamide T=0°C; 18 h;
参考文献
WO2008/141020 A1, ;
Page/Page column 50 ;
WO 2008/141020 A1
反应条件
pyridine; hydrogenchloride in tetrahydrofuran; hexane
反应条件
in xylene T=100°C; 4 h;
参考文献
WO2006/24820 A1, ;
Page/Page column 124 ;
反应条件
1: methylhydrazine With hydrogenchloride in ethanol T=0°C; 0.5 h; 2: ethyl 2-ethoxymethylidene-3-oxo-3-trifluoromethylpropionate in ethanol T=0°C; 18 h; 3: With sodium carbonate in ethanol; water
参考文献
WO2008/59370 A2, ;
Page/Page column 52 ;
WO 2008/059370 A2
反应条件
sodium hydroxide in water; toluene
反应条件
in water; toluene Cooling with ice;
参考文献
EP2263999 A1, ;
Page/Page column 21 ;
反应条件
hydrogenchloride; potassium hydroxide; sodium chloride in water
反应条件
hydrogenchloride; sodium hydroxide; tetrabutylammomium bromide in water; toluene
反应条件
T=180°C; 16 h; Product distribution / selectivity;
参考文献
WO2006/45504 A1, ;
Page/Page column 5 ;
