1.1: N-methylmorpholine / CH2Cl2 / 0.33 h / -15 °C 2.1: N-methylmorpholine / CH2Cl2 / -15 - 20 °C 2.2: H2 / Pd/C / methanol / 24 h / 4654.46 Torr View Scheme

1: With 4-methyl-morpholine in dichloromethane T=-15 - 20°C; 2: With hydrogen; palladium on activated charcoal in methanol P=4654.46 Torr; 24 h; Further stages.;

hydrogen; palladium in water; acetic acid; tert-butyl alcohol Yield given;

1: triethylamine / acetonitrile / 4 h / 20 °C 2: H2 / Pd / acetic acid; 2-methyl-propan-2-ol; H2O View Scheme

ammonia; water T=37°C;

1: N-(9H-fluoren-9-ylmethyloxycarbonylamino)-L-alanine With N-ethyl-N,N-diisopropylamine in dichloromethane 2 h; 2-chlorotrityl chloride resin; Inert atmosphere; 2: With piperidine in N,N-dimethyl-formamide 0.333333 h; 2-chlorotrityl chloride resin; 3: N-(fluoren-9-ylmethoxycarbonyl)-L-Val Further stages;

1: dicyclohexylcarbodiimide; CH2Cl2 View Scheme