(E)-4-溴-3-甲氧基丁-2-烯酸乙酯合成路线 （共 10 条）
反应条件
N-bromosuccinmide T=110 - 115°C;
参考文献
Pelter, Andrew; Al-Bayati, Redha I. H.; Ayoub, Miqdad T.; Lewis, Wynn; Pardasani, Pushpa; Hansel, Rudolf
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 717 - 742
反应条件
1: 100 percent / cc. HCl / methanol 2: 95 percent / NBS / 110 - 115 °C View Scheme
参考文献
Pelter, Andrew; Al-Bayati, Redha I. H.; Ayoub, Miqdad T.; Lewis, Wynn; Pardasani, Pushpa; Hansel, Rudolf
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 717 - 742
反应条件
1: 74 percent / anhydr. ZnBr2 / xylene / 8 h / Heating 2: 5.7 g / n-butyl-lithium, diisopropylamide / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 0.33 h / -78 °C 3: 94 percent / tetrahydrofuran / -78 deg C, 1 h, 20 deg C, 1 h 4: 83 percent / benzene sulphonyl chloride / CH2Cl2 / 24 h / Ambient temperature View Scheme
参考文献
Pelter, Andrew; Al-Bayati, Redha I. H.; Ayoub, Miqdad T.; Lewis, Wynn; Pardasani, Pushpa; Hansel, Rudolf
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 717 - 742
参考文献
Ayoub, Mikdad T.; Shandala, Mowafak Y.; Bashi, Galia M. Gussba; Pelter, Andrew
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 697 - 699
反应条件
ammonium hydroxide 24 h; Ambient temperature;
参考文献
James, Gwyn D.; Mills, Stuart D.; Pattenden, Gerald
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 21 p. 2581 - 2584
反应条件
zinc dibromide in xylene 6 h; Heating;
参考文献
Shandala, Mowafak Y.; Ayoub, Mikdad T.; Mohammad, Moyayed J.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 1753 - 1754
参考文献
Ayoub, Mikdad T.; Shandala, Mowafak Y.; Bashi, Galia M. Gussba; Pelter, Andrew
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 697 - 699
参考文献
Ayoub, Mikdad T.; Shandala, Mowafak Y.; Bashi, Galia M. Gussba; Pelter, Andrew
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 697 - 699
反应条件
1: 74 percent / anhydr. ZnBr2 / xylene / 8 h / Heating
2: 5.7 g / n-butyl-lithium, diisopropylamide / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 0.33 h / -78 °C
3: 70 percent / tetrahydrofuran; H2O / 2 h / Ambient temperature
4: 75 percent / methanesulphonyl chloride / pyridine / 20 h / Ambient temperature
View Scheme
参考文献
Pelter, Andrew; Al-Bayati, Redha I. H.; Ayoub, Miqdad T.; Lewis, Wynn; Pardasani, Pushpa; Hansel, Rudolf
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 717 - 742
反应条件
1: 74 percent / anhydr. ZnBr2 / xylene / 8 h / Heating
2: 5.7 g / n-butyl-lithium, diisopropylamide / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 0.33 h / -78 °C
3: 94 percent / tetrahydrofuran / -78 deg C, 1 h, 20 deg C, 1 h
4: 93 percent / zinc bromide / CH2Cl2 / -95 deg C 1 h, RT., 2 day
View Scheme
参考文献
Pelter, Andrew; Al-Bayati, Redha I. H.; Ayoub, Miqdad T.; Lewis, Wynn; Pardasani, Pushpa; Hansel, Rudolf
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 717 - 742
