4-(二甲氨基)丁醛缩二乙醇合成路线 （共 14 条）
反应条件
iodine; magnesium in benzene 3.25 - 4.33333 h; Heating / reflux;
参考文献
NATCO PHARMA LIMITED
Patent: WO2003/101931 A2, 2003 ;
Location in patent: Page 14-15 ;
反应条件
1: 1-dimethylamino-3-chloropropane With iodine; magnesium in benzene 3.25 - 4.25 h; Heating / reflux; 2: diethyl phenyl orthoformate in benzene 3 h;
参考文献
NATCO PHARMA LIMITED
Patent: WO2003/101931 A2, 2003 ;
Location in patent: Page 19 ;
反应条件
titanium(IV) isopropylate; sodium tetrahydroborate 1.) diglyme, 60 deg C, 30 min then r.t., 30 min; 2.) diglyme, r.t., 2.5 h then 60 deg C, 2.5 h; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 35, # 15 p. 2401 - 2404
参考文献
Croatica Chemica Acta, , vol. 36, p. 103,106
参考文献
Justus Liebigs Annalen der Chemie, , vol. 410, p. 63
反应条件
1: methanol; sodium hydrogencarbonate 2: 2-amino-ethanol View Scheme
参考文献
Croatica Chemica Acta, , vol. 36, p. 103,106
反应条件
in N,N-dimethyl-formamide
参考文献
Zhurnal Organicheskoi Khimii, , vol. 1, p. 1973 - 1976,2011 - 2014
反应条件
sulfuric acid Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Chen; Senanayake; Bill; Larsen; Verhoeven; Reider
Journal of Organic Chemistry, 1994 , vol. 59, # 13 p. 3738 - 3741
反应条件
1: 4-(1,2,4-triazol-1-ylmethyl)phenylhydrazine With sulfuric acid T=65 - 70°C; Fischer Indole Synthesis; 2 h; 2: 4-(N,N-dimethylamino)butyraldehyde diethyl acetal T=20 - 70°C; Fischer Indole Synthesis; 3 - 4 h; 3: With ammonia; water T=15 - 20°C; pH=8.5 - 9;
参考文献
WO2008/149152 A1, ;
Page/Page column 13 ;
反应条件
1: With sulfuric acid in water T=35 - 42°C; Fischer Indole cyclization; 9 h; 2: With sodium hydroxide; water T=0 - 5°C; pH=10.5 - 11; Product distribution / selectivity;
参考文献
WO2008/75163 A2, ;
Page/Page column 11-12 ;
