4-(二甲氨基)丁醛缩二乙醇合成路线 （共 14 条）
反应条件
1: 1-(4-Aminophenyl)methyl-1,2,4-triazole With hydrogenchloride in water T=25 - 30°C; 0.333333 - 0.5 h; 2: With sodium nitrite in water T=0 - 5°C; 3 h; 3: 4-(N,N-dimethylamino)butyraldehyde diethyl acetal With sulfuric acid; ammonia; sodium sulfite Product distribution / selectivity; more than 3 stages;
参考文献
WO2006/137083 A1, ;
Abstract ;
反应条件
1: (S)-4-(4-aminobenzyl)-1,3-oxazolidin-2-one With hydrogenchloride; sodium nitrite in water T=0°C; 0.5 h; 2: With Na2S2O5; sodium hydroxide in water T=2 - 60°C; 1.25 h; Heating / reflux; 3: 4-(N,N-dimethylamino)butyraldehyde diethyl acetal With hydrogenchloride; sodium hydroxide more than 3 stages;
参考文献
NATCO PHARMA LIMITED; KOMPELLA, Amala, Kisham; RACHAKONDA, Sreenivas; ADIBHATLA KALI SATYA, Bhujanga, Rao; VENKAIAH CHOWDARY, Nannapaneni
Patent: WO2008/7390 A2, 2008 ;
Location in patent: Page/Page column 6 ;
反应条件
in water T=90°C; Fischer Indole Synthesis; 3 h; Heating / reflux;
参考文献
AstraZeneca AB
Patent: EP1227095 A2, 2002 ;
Location in patent: Example 1 ;
反应条件
T=90 - 98°C; 2.5 h; Heating / reflux; Product distribution / selectivity;
参考文献
ZENTIVA, A.S.
Patent: WO2008/104135 A1, 2008 ;
Location in patent: Page/Page column 4 ;
